兰索拉唑vs Omeprazole
兰索拉唑and Omeprazole are two drugs coming under the drug class of proton pump inhibitors. Proton pumps are situated in mitochondrial membranes, which mean they are in all most all cells. The importance of these drugs is that they selectively inhibit proton pumps in the stomach lining. The mechanism of action is to inhibit H+/K+ ATPase enzyme selectively in gastric parietal cells. In organic chemistry, both these drugs are benzimidazoles containing substituted benzene ring and imidazole ring.
兰索拉唑
兰索拉唑is also known by the trade namePrevacid。This drug is used for the complications related to excessive acid secretion in the stomach and also diseases like Zollinger- Ellison syndrome. Lansoprazole could be given as a combination with antibiotics. The pill should be swallowed as a whole without chewing because it may damage the coating which is designed to protect the stomach. Granular suspension should be taken only with apple juice. Sometimes the granular suspension is delivered through nasogastric feeding tube.
There are a number of harmful effects of the drug. Animal studies have shown the chronic usage may cause stomach cancers although it is not confirmed with humans up to date. Tendency to increase bone fracture in hips, wrists, and spine is also found through clinical studies. Lansoprazole has various side effects. Uneven and fast heart rate, muscle weakness, diarrhea, coughing and choking, headache, and troubles in memory are some of the serious side effects. In addition, weight change, stomach pain, insomnia is also experienced. Lansoprazole should not be taken if one is allergic to the drug. It should not be taken while under medication of other benzimidazole drugs. A person who is taking HIV AIDS medicine, ampicillin, blood thinner, water pills, iron tablets, diabetes medicine always should seek medical advice before taking Lansoprazole. Lansoprazole intake is not advisable if a person has suffered from liver disease or has low Magnesium levels in the blood. If a person is taking sucralfate (Carafate) while taking Lansoprazole, it is better to at least give a 30 minute gap between the two intakes because sucralfate decreases Lansoprazole absorption. The daily dosage of Lansoprazole is 30mg and is larger than Omeprazole dosage of 20mg. Lansoprazole is not available for purchase without prescriptions.
Omeprazole
Omeprazole is also known by the trade namesPrilosecandZegerid。这是另一种质子泵抑制剂。它经常处方以治疗与胃中过度酸分泌有关的并发症，例如对食道和胃食管反流疾病（GERD）的损害。这种药物不能立即减轻胃灼热。片剂应在饭前30分钟服用。除了对兰索拉唑说的有害作用外，这还表明能够降低维生素B12吸收并因此导致B12缺乏症。两种药物的副作用和过量作用相似。
兰索拉唑(Prevacid) vs Omeprazole (Prilosec)
• Lansoprazole use requires prescription, but Omeprazole could be used with or without a prescription.
• Daily dose of Lansoprazole is 30mg, but daily dose of Omeprazole is 20mg.
• Lansopazole is expensive than Omeprazole.
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