Thekey difference在历史冰箱和液氮之间histofreezer is a cryogenic material containing a mixture ofdimethyl ether和丙烷whereas the liquid nitrogen is a cryogenic fluid containing氮in a liquid state.
Cryogenics is a field of science in which we study the behaviour of materials at extremely low temperatures. Cryogenic fluids are the mediums that we use to store the materials at very low temperatures. Histofreezer and liquid nitrogen are two such cryogenic fluids.
CONTENTS
1.Overview and Key Difference
2.What is Histofreezer
3.What is Liquid Nitrogen
4.Side by Side Comparison – Histofreezer vs Liquid Nitrogen in Tabular Form
5.概括
What is Histofreezer?
Histofreezer is a cryogenic material that we call a “cryogen”. It is an environmentally safe mixture of dimethyl ether and propane. These are gaseous components. Therefore, when we spray these gases onto a fam bud through an applicator, it produces a lower temperature that is around -55°C via its heat of vaporization. The scientist Dr William Swart invented this cryogen while trying to find an alternative to liquid nitrogen. He tried to find this alternative because of the intolerable freezing temperature of liquid nitrogen. Thus, the freezing temperature of histofreezer is warmer than liquid nitrogen. However, this cryogen is more expensive because it has a high cost per freeze. Moreover, it can give fewer freezes per one canister, and it has a short shelf life and expiration date.
在考虑Histofreezer的功效时,通过19年的研究证明了其功效。它比切割或燃烧更容易,更快,而且侵入性也不那么侵入性。此外,这对患者和环境也非常安全。它还提供了一种简单的单手用途,对用户的风险较低。
What is Liquid Nitrogen?
液氮是液态的氮。该液体存在于极低的温度下。沸点约为-195.79°C。它是无色而清晰的。科学家ZygmuntWróblewski和Karol Olszewski发明了这种化合物。

Figure 01: Liquid Nitrogen
Liquid nitrogen is a cryogenic fluid. It can cause rapid freezing when contact with living tissues. We can store this liquid safely in vacuum flasks, but the slow boiling of the liquid cause evolution of nitrogen gas. Moreover, we should handle this compound very carefully because it can cause cold burns. Therefore, we should use special gloves when handling this liquid. In addition to that, it can reduce the oxygen content in air and acts as an asphyxiant. When using it as a cryogen, scientists often tend to search for alternatives because the freezing temperature of this cryogen is intolerable to many patients.
What is the Difference Between Histofreezer and Liquid Nitrogen?
Histofreezer is a cryogenic material which we call a “cryogen”. It contains a mixture of dimethyl ether and propane in gaseous form. Liquid nitrogen, on the other hand, is a cryogenic fluid. It contains nitrogen in its liquid state. This is one main difference between histofreezer and liquid nitrogen. More importantly, the freezing temperature of histofreezer is -55°C and also it has a tolerable freezing temperature. Whereas, the freezing temperature of the liquid nitrogen is −195.79 °C. Therefore, it has an intolerable freezing temperature. Therefore, the freezing temperature is another important difference between histofreezer and liquid nitrogen. Apart from that, histofreezer is environmentally safe. But, liquid nitrogen can reduce the oxygen in air by acting as an asphyxiant.
概括– Histofreezer vs Liquid Nitrogen
组织冻结仪和液氮都是冷冻剂。组织冻结仪和液氮之间的关键区别在于,冰冻仪含有二甲基醚和丙烷的混合物,而液氮含有液态含氮。
Reference:
1. Helmenstine, Anne Marie, Ph.D. “Liquid Nitrogen Facts.” ThoughtCo, Jun. 22, 2018.Available here
Image Courtesy:
1.”Liquidnitrogen”By Cory Doctorow aka gruntzoki(CC BY-SA 2.0)通过Commons Wikimedia
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