G6PD和镰状细胞有什么区别| Compare the Difference Between Similar Terms

TheG6PD和镰状细胞之间的关键区别is that G6PD (glucose 6 phosphate dehydrogenase) is an enzyme that protects红细胞从血液解而镰状细胞是红细胞的异常形状，导致红细胞溶血。

溶血性贫血是一种血液疾病。在这种情况下，红细胞被破坏的速度比合成的速度快。溶血是指红细胞的破坏。红细胞的功能是将氧气通过体内。因此，如果人们的红细胞水平低，则倾向于患有贫血。这种贫血状况可以继承或获得。因此，G6PD和镰状细胞是与溶血有关的两个术语。

内容

1.Overview and Key Difference
2.What is G6PD
3.What is Sickle Cell
4.Similarities – G6PD and Sickle Cell
5。G6PD vs Sickle Cell in Tabular Form
6。概括

What is G6PD?

G6PD (glucose 6 phosphate dehydrogenase) is an enzyme that protects red blood cells from haemolysis. G6PD is widely distributed in many species, like bacteria to humans. This enzyme is generally a dimer that consists of two identical monomers. Glucose 6 phosphate is the substrate that stimulates glucose 6 phosphate dehydrogenase.

This enzyme participates in the pentose phosphate metabolic pathway that supplies reducing energy to cells. The normal function of this enzyme is reducingNADPto纳德while oxidizing glucose 6 phosphate. The NADPH maintains a level of glutathione in red blood cells. Glutathione protects cells against oxidative damage from compounds like hydrogen peroxide. Therefore, normally X linked genetic deficiency of G6PD causes non-immune haemolytic anaemia in humans.

Figure 01: G6PD

G6PD酶缺乏主要影响男性。葡萄糖6磷酸脱氢酶缺乏症通常可能引起贫血症状，例如皮肤和眼睛的白色，深色尿液，疲劳，呼吸急促和快速心率。此外，葡萄糖6磷酸脱氢酶缺乏症的人由于简单的感染，摄入粉红色豆或食用某些药物（如抗生素，抗染料剂或抗性药物）而患有溶血性贫血。这种遗传状况的治疗方法包括消除导致正常症状的触发因素。贫血也可以输血。但是，许多患有这种遗传疾病的人从未经历过任何迹象或症状，并且通常没有意识到这种情况。

What is Sickle Cell?

Sickle cell is an abnormal shape of red blood cells that causes haemolysis of red blood cells. Sickle cell disease is a group of inherited red blood cells disorder. In this condition, people won’t have enough healthy red blood cells to carry oxygen throughout the body. Sickle cell disease typically follows the autosomal recessive inheritance pattern. Haemoglobin is the protein inside the red blood cells. Haemoglobin consists of four subunits: two alpha globin subunits and two beta globin subunits.

图02：镰状细胞

In sickle cell disease, a mutation in the HBB gene that forms beta globin subunits of haemoglobin changes the shape of red blood cells from biconcave to a sickle shape. This common mutation is a single nucleotide substitution that replaces the amino acid in 6^thposition beta globin protein from glutamine to valine. Therefore, sickle cell disease triggers haemolysis and causes anaemia in patients. The typical symptoms of sickle cell disease are anaemia, episodes of pain, frequents infections, delayed growth, vision problems, yellow tint in skin etc. Moreover, the treatment for this condition is normally blood transfusions. But bone marrow transplantation is a permanent solution.

G6PD和镰状细胞之间有什么相似之处？

G6PD and sickle cell are two terms related to haemolysis.
Both are important concerns in patients with haemolytic anaemia.
They are helpful factors to determine the normal function of red blood cells.
它们都与疾病有关。

G6PD和镰状细胞有什么区别?

G6PD is an enzyme that protects red blood cells from haemolysis while the sickle cell is an abnormal shaped red blood cell that causes haemolysis of red blood cells. So, this is the key difference between G6PD and sickle cell. Furthermore, G6PD deficiency causes haemolytic anaemia, while a surplus of the sickle cell causes haemolytic anaemia.

以下信息图列出了与表格形式的G6PD和镰状细胞之间的差异，以与并排比较。

概括– G6PD vs Sickle Cell

In a recent research study, it was identified that patients with sickle cell disease (SCD) are more prone to haemolysis due to the shape of red blood cells and if they are deficient in G6PD enzyme. G6PD is an enzyme that protects red blood cells from haemolysis. The key difference between G6PD and sickle cell is that G6PD is an enzyme that protects red blood cells from haemolysis while sickle cell is an abnormal shape of red blood cells that causes the haemolysis of red blood cells.