Difference Between Megaloblastic and Pernicious Anemia

Thekey differencebetween megaloblastic and pernicious anemia is that大型细胞贫血是一种贫血红细胞are larger than the normal size while pernicious anemia is a type of megaloblastic anemia that happens due to deficiency ofvitamin B12.

Red blood cells (RBC) are the most common type of blood cells. RBCs deliver oxygen to body tissues. Anemia is a condition which refers to the low capacity of red blood cells to transport enough oxygen to body tissues or low concentration ofhaemoglobin在红细胞中。这是多个因素的结果，包括RBC的产生不足，RBC过度破坏，红细胞异常或失血。大型细胞贫血是一种贫血疾病。恶性贫血是由维生素B12缺乏引起的一种巨型贫血。由于巨型贫血，人体组织和器官无法获得足够的氧气。

内容

1.Overview and Key Difference
2.What is Megaloblastic Anemia
3.What is Pernicious Anemia
4.大型贫血和恶性贫血之间的相似之处
5.并排比较 - 表格形式的巨型细胞与有害贫血
6.概括

What is Megaloblastic Anemia?

Megaloblastic anemia is a type of anemia condition which is characterized by the presence of large red blood cell precursors called megaloblasts in the bone marrow. In this condition, red blood cells are larger than normal red blood cells. There is also a low number of red blood cells in the circulation. Megaloblastic anemia arises due to impaired DNA synthesis leading to inhibition ofnuclear division.

There are two main causes of megaloblastic anemia. They are vitamin B12 deficiency and folate deficiency. Megaloblastic anemia caused by vitamin B-12 deficiency is referred to as pernicious anemia. Moreover, folate is needed for the development of healthy red blood cells. Therefore, vitamin B12 and folate deficiency are the most common causes of megaloblastic anemia.

What is Pernicious Anemia?

Pernicious anemia is a blood disease that happens due to the insufficient uptake of vitamin B12. In pernicious anemia condition, large, immature, nucleated red blood cells circulate in the blood. The uptake of vitamin B12 decreases when the body lacks an intrinsic factor in the gastric mucosa since intrinsic factor facilitates the absorption of dietary vitamin B12 in the small intestine. Vitamin B12 is needed for hemoglobin production. In other words, vitamin B12 aids the body to produce healthy red blood cells. Therefore, pernicious anemia is a type of vitamin B12 deficiency anemia. The major cause of pernicious anemia is the loss of stomach cells that produce intrinsic factor.

恶性贫血的症状是疲劳，无力，头痛，胸痛，体重减轻和皮肤苍白。由于恶性贫血，神经和其他器官可能会永久损害。也有患胃癌的风险。维生素B12药丸和饮食的改变是有害贫血的两种类型。

What are the Similarities Between Megaloblastic and Pernicious Anemia?

• Pernicious anemia is a type of megaloblastic anemia.
• 维生素B12的缺乏症是造成巨大细胞和恶性贫血的原因。
• Due to both diseases, body tissues and organs don’t get enough oxygen.

巨型细胞和恶性贫血有什么区别？

Megaloblastic anemia is a type of blood disease in which bone marrow produces unusually larger red blood cells than the normal. Most common causes of megaloblastic anemia are vitamin b12 and folate deficiencies. Pernicious anemia is a type of megaloblastic anemia which is caused by vitamin B-12 deficiency. So, this is the key difference between megaloblastic and pernicious anemia. As a result of megaloblastic anemia, body tissues and organs do not get enough oxygen.

以下是巨型细胞和恶性贫血之间的差异的摘要。

概括– Megaloblastic vs Pernicious Anemia

Megaloblastic anemia is a condition in which the bone marrow produces unusually large, structurally abnormal, immature red blood cells. It happens due to the impaired DNA synthesis leading to inhibition of nuclear division. Major causes are vitamin B12 and folate deficiencies. Pernicious anemia is a type of megaloblastic anemia in which our body fails to produce enough red blood cells due to the deficiency of vitamin B12. It is a result of the lack of intrinsic factor. Thus, this is the summary of the difference between megaloblastic and pernicious anemia.

Reference:

1.哈里斯，阿尼斯和普里扬卡·巴塔查里亚。“巨型细胞贫血”。ncbi.nlm.nih.gov，2020年，Available here.
2.“有害贫血|国家心脏，肺和血液研究所（NHLBI）”。nhlbi.nih.gov，2020年，Available here.

Image Courtesy:

1. “Hypersegmented neutrophil” By Paul Weisz Carrington, M.D (Public Domain) viaCommons Wikimedia
2. “Metaplastic atrophic gastritis – body – chromogranin A — intermed mag” By Nephron – Own work(CC BY-SA 4.0)viaCommons Wikimedia