lamellipodia和丝状虫之间的差异

Thekey difference在Lamellipodia和Filopodia之间lamellipodia arecytoskeletalactin projections present in the mobile edges of the cells while filopodia are thincytoplasmicprotrusions that extend from the leading edge of the mobile cells.

Lamellipodia and filopodia are two cellular extensions commonly used in cell probing and migration. These structures sense the extracellular conditions and locomote respectively. Hence, they are essential structures for cell mobility. Also, microspikes refer to these lamellipodia and filopodia, and compose actin filaments. Both structures are present on the leading edge of a migrating cell.

内容

1.Overview and Key Difference
2.What is Lamellipodia
3.What is Filopodia
4.Similarities Between Lamellipodia and Filopodia
5.Side by Side Comparison – Lamellipodia vs Filopodia in Tabular Form
6.概括

What are Lamellipodia?

Lamellipodia are cytoskeleton protrusions in the flat ribbon-shape and present at the periphery of a migrating cell. These protrusions are enriched with a branched network of bi-dimensional dendric array of actin filaments. In other terms, a lamellipodium contains a two-dimensional actin mesh which propels the whole cellular structure across a substrate. Therefore, they are extremely vital for细胞迁移.

Lamellipodia像电动机一样工作，并在细胞迁移过程中向前拉细胞。因此，它是在通气细胞的前沿边缘存在的一个特征。薄片主要存在于鱼类和青蛙的角质形成细胞中，这使它们可以以10-20μm/min的速度在上皮表面上移动。即使Lamellipodia与细胞分开，它们仍然可以自由移动。

What are Filopodia?

Filopodia are membranous cytoplasmic protrusions present in a cell to probe the extracellular environment. Hence, they act as antennas. Filopodia are thin protrusions generally present in the free end of migratory tissues embedded within or extending from the lamellipodium. These protrusions are commonly present in the growth cones of neurons, protruding end of migratory cells, epithelial sheets and in individual cells such as fibroblasts.

丝状菌含有肌动蛋白丝，并排列在直径为60-200 nm的平行束中。因此，每个丝霉植物含有10-30个肌动蛋白丝。同样，结合蛋白（例如fascin和fimbrin）将这些肌动蛋白丝固定在一起。这些丝的方向发生了，因此刺尾端朝向延伸的膜。每个丝霉的远端包含细胞表面受体。这些受体充当探测外部环境的传感器。丝状的组装包含三个基本步骤：丝状成核，持续的铁丝网末端伸长和丝状捆绑。

What are the Similarities Between Lamellipodia and Filopodia?

• Lamellipodia and filopodia are made up of actin filaments.
• Also, both structures are present on the leading edge of migrating cells.
• Both lamellipodia and filopodia sense the extracellular environment and help in cellular migration.

What is the Difference Between Lamellipodia and Filopodia?

Lamellipodia are cytoskeletal protein actin projections that occur at the leading edge of the migratory cells. Whereas, filopodia are slender cytoplasmic projections that extend beyond the leading edge of lamellipodia in migrating cells. Therefore, this is the key difference between lamellipodia and filopodia. Furthermore, lamellipodia are highly specialized for cell migration while filopodia are specialized for sensing the external environment. Hence, we can consider this also as a difference between lamellipodia and filopodia.

The below infographic summarizes the difference between lamellipodia and filopodia.

概括– Lamellipodia vs Filopodia

Lamellipodia and filopodia are two extensions present in the leading edges of migratory cells. Both contain actin filaments. However, lamellipodium is a cytoskeletal extension but, filopodium is a cytoplasmic extension. Hence, this is the key difference between lamellipodia and filopodia. Moreover, even though both extensions help in cell migration, filopodia can probe the extracellular environment. Whereas, lamellipodia are highly specialized for cell migration. In fish and frog, the lamellipodia are present in the keratinocytes. Thus, this is a summary of the difference between lamellipodia and filopodia.

Reference:

1. “Lamellipodium.” NeuroImage, Academic Press,Available here.
2. “What Are Filopodia?” MBInfo,Available here.

Image Courtesy:

1. Chris1387（谈话）的“ GrenturyCones” - 自制(CC BY-SA 3.0)viaCommons Wikimedia
2. Lubov Czech，Tatyana Svitkina和Changsong Yang - Plos Biology Image Image，第1卷。5（11）2007年11月。(CC BY 2.5)viaCommons Wikimedia