这关键区别从头和打捞途径之间de novo synthesis of嘌呤nucleotides refers to the process that utilizes small molecules such as phosphoribose, amino acids, CO2作为生产嘌呤核苷酸的原材料,而嘌呤合成的打捞途径是指利用嘌呤碱和嘌呤核苷的过程,以产生嘌呤核苷酸。
核苷酸是核酸的组成部分。此外,一些核苷酸,尤其是ATP,在能量转移有重要的作用。一些work as secondary messengers as well. A nucleotide has three components: a sugar, a nitrogen base and a phosphate group. Synthesis of nucleotides takes place via different pathways. De novo pathway and salvage pathway are two main pathways of synthesis of purine nucleotides. De novo pathway acts as the main pathway while salvage pathway is important for purine nucleotide synthesis in the brain and bone marrow. Therefore, the de novo pathway is a major pathway while salvage pathway is a minor pathway.
CONTENTS
1。概述和关键差异
2。What is De Novo Pathway
3。什么是打捞路径
4。从头和打捞途径之间的相似之处
5。并排比较 - 表格形式的从头vs打捞途径
6.Summary
从头途径是什么?
De novo pathway is a metabolic pathway that begins with small molecules and synthesizes new complex molecules. Thus, de novo synthesis of purine nucleotides refers to the process that utilizes small molecules to produce purine nucleotides. It uses raw materials such as phosphoribose, amino acids (glutamine, glycine, and aspartate), CO2,,etc., to synthesize purine nucleotides. Moreover, the de novo pathway is the main pathway that synthesizes purine nucleotides.
In de novo pathway, ribose -5-phosphate works as the starting material. Then, it reacts with ATP and converts into phosphoribosyl pyrophosphate (PRPP). Next, glutamine donates its amide group to PRPP and converts it to 5-phosphoribosylamine. Thereafter, the 5-phosphoribosylamine reacts with glycine and becomes glycinamide ribosyl 5-phosphate, and later, it converts into formylglycinamide ribosyl 5-phosphate. Glutamine donates its amide group and converts formylglycinamide ribosyl 5-phosphate into formylglycinamideine ribosyl 5-phosphate. Then the imidazole ring of the purine completes its ring form. Finally, with the incorporation of CO2and undergoing several further reactions, it becomes the inosine monophosphate (IMP). IMP is the immediate precursor molecule of theadenosine monophosphate (AMP)and guanosine monophosphate (GMP), which are purine nucleotides.
什么是打捞路径?
Salvage pathway of purine nucleotide synthesis refers to the process of synthesizing nucleotides from purine bases and purine nucleosides. Purine bases and purine nucleotides are constantly produced in the cells as a result of the metabolism of nucleotides such as polynucleotide degradation. Moreover, these bases and nucleosides also enter our body by the food we consume.
嘌呤核苷酸合成的挽救途径是次要途径。它主要由磷酸贝糖基转移酶反应发生。两种特异性酶,腺嘌呤磷酸蛋白基转移酶(APRT)和黄嘌呤 - 瓜氨酸磷酸贝糖基转移酶(HGPRT),催化磷酸贝糖基转移酶反应。它们催化核糖5'-磷酸部分从磷酸磷酸磷酸磷酸(PRPP)转移到嘌呤碱基以产生嘌呤核苷酸。在无法从头合成的某些组织中,打捞途径很重要。
What are the Similarities Between De Novo and Salvage Pathway?
- De novo and salvage are two pathways of nucleotide synthesis.
- 此外,两种组装核糖核苷酸都可用于合成DEOXYRIBON核苷酸作为DNA。
- 此外,反馈抑制可以调节这两种途径。
从头和打捞途径有什么区别?
核苷酸合成是通过两种途径发生的:从头途径和打捞途径。从头途径利用小分子产生核苷酸,而打捞途径利用预先形成的碱和核苷来产生核苷酸。因此,这是从头和打捞途径之间的关键区别。
此外,从头和打捞途径之间的另一个显着差异是,从头途径发生在所有细胞类型中,而打捞途径发生在某些不可能的从头过程的组织中。此外,从头途径是主要途径,而打捞途径是核苷酸合成的次要途径。
以下信息图显示了与从头和打捞途径之间的另一个差异有关的更多比较。
摘要 - 从头vs打捞途径
从头途径是从小分子新合成复合化合物的途径。打捞途径是利用先前制成的化合物以合成复杂化合物的途径。在核苷酸合成中,可以看到从头和打捞途径。因此,嘌呤核苷酸合成的从头途径是指利用核糖糖,氨基酸,CO等小分子的过程2, one carbon unit, etc. to produce new purine nucleotides. On the other hand, salvage pathway of purine nucleotide synthesis refers to the process that utilizes previously made bases and nucleosides to produce purine nucleotides. Thus, this is the key difference between de novo and salvage pathway. Furthermore, all cell types have the ability to carry out de novo pathway while only certain tissues are able to carry out salvage pathway.
参考:
1。“Purine Nucleotide.” Purine Nucleotide – an Overview | ScienceDirect Topics,在这里可用。
2. Nyhan,William L.“通过打捞途径的核苷酸合成。”威利在线图书馆,美国癌症协会,2014年12月9日,在这里可用。
图片提供:
1. Ayacop的“ Purine-De-Novo” - 自己的作品,公共领域)下议院维基梅迪亚
2. Torres RJ,Puig JG - Torres RJ,Puig JG的“ HPRT代谢”。低黄嘌呤 - 瓜氨酸磷脂转移酶(HPRT)缺乏症:Lesch-Nyhan综合征。orphanet j Rare。2,1。2007。PMID18067674。DOI:10.1186/1750-1172-2-48(CC由3.0)通过下议院维基梅迪亚
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