What is the Difference Between v-SNARE and t-SNARE

Thekey differencebetween v-SNARE and t-SNAREis that v-SNARE is associated with the membrane of transportvesicle在buddingwhile t-SNARE is associated with nerve terminal membranes.

SNARE (an acronym derived from soluble N-ethylmaleimide sensitive fusion protein (NSF) attachment receptor) is a large protein family that consists of 24 different types ofSaccharomyces cerevisiaeand 60 different types of mammalian cells. The main function of SNARE proteins is to mediate the fusion of the vesicle with target membranes. In other words, SNARE proteins mediate胞吞作用. They also mediate the fusion of membrane-bound compartments such as lysosomes. SNAREs can be divided into two main categories: v (vesicle) – SNARE and t (target) – SNARE.

内容

1.Overview and Key Difference
2.What is v-SNARE
3.What is t-SNARE
4.相似之处——v-SNARE和t-SNARE
5.v-SNARE vs t-SNARE in Tabular Form
6.Summary – v-SNARE vs t-SNARE

What is v-SNARE?

v-SNARE is a type of SNARE protein associated with the membrane of transport vesicle during the process of budding, which mediates exocytosis. VAMP7 and VAMP 8 are two main examples of v-SNARE proteins. They contain more than 70% of branched amino acids within the transmembrane domain region.

V-SNARE aids exocytosis of large zymogen granules and mast cell vesicles, facilitating rapid pore expansion and release of bulky molecules such as interferon. R-SNAREs are members similar to v-SNARE, which mediate vesicle fusion similar to v-SNARE.

什么是T-SNARE？

T-SNARE是一种与神经末端膜相关的核心蛋白，并形成稳定的亚复合物，并作为V-SNARE的指南。语法1和SNAP-25是较大蛋白质家族（例如T-Snare）的成员。

Their specific localization to subcellular membranes defines where transport vesicles bind and fuse. Q-SNARE are members similar to t-SNARE that mediate vesicle fusion similar to t-SNARE.

What are the Similarities Between v-SNARE and t-SNARE?

• V-SNARE和T-SNARE是SNARE蛋白的亚型。
• They help to mediate the fusion of the vesicle with target membranes.
• Both play a major role in the process of exocytosis.

What is the Difference Between v-SNARE and t-SNARE?

The key difference between v-SNARE and t-SNARE is that v-SNARE is usually incorporated into the membrane of the transport vesicle during the process of budding, while t-SNARE is associated with nerve terminal membranes. Other terms for v-SNARE and t-SNARE are vesicle SNARE and target-SNARE, respectively. Another difference between v-SNARE and t-SNARE is their function. The function of v-SNARE is to mediate the process of exocytosis, while the function of t-SNARE is to form stable subcomplexes and function as a guide for v-SNARE. Moreover, VAMP7 and VAMP 8 are two main types of v-SNARE while Syntaxin 1 and SNAP-25 are two main types of t-SNARE.

以下信息图显示了与表格形式的V-SNARE和T-SNARE之间的差异.

Summary – v-SNARE vs t-SNARE

SNARE is a large protein family. v-SNARE is a type of SNARE protein associated with the membrane of transport vesicle during the process of budding, which mediates exocytosis. t-SNARE is a type of SNARE protein associated with the nerve terminal membranes. Moreover, the main function of SNARE proteins is to mediate the fusion of the vesicle with target membranes. In other words, SNARE proteins mediate exocytosis. t-SNAREs, on the other hand, form stable subcomplexes and function as a guide for v-SNARE. So, this summarizes the difference between v-SNARE and t-SNARE.

Reference:

1. Han, Jing, et al. “SNARE蛋白在膜融合中的多方面作用.” Frontiers in Physiology, Frontiers Media S.A., 20 Jan. 2017.
2. “军鼓（蛋白质）.” SNARE (Protein) – an Overview | ScienceDirect Topics.

Image Courtesy:

1.“”囊泡对接1” By Kimgh5698 – Own work(CC BY-SA 3.0)via Commons Wikimedia
2. “Classificació SNAREs wiki” By BQUB17-ABriones – Own work(CC BY-SA 4.0)via Commons Wikimedia