Key Difference – Scleritis vs Episcleritis The key difference between Scleritis and Episcleritis is that Scleritis, which often occurs in association with autoimmune diseases, is an inflammatory disease that affects the white outer coating of the eyeball (sclera) whereas Episcleritis is a benign, self-limiting inflammatory disease affecting the episclera (Episclera lies between the outermost […]