Thekey difference在血管生成和新血管形成之间angiogenesis primarily refers to the formation of new blood vessels from pre-existing blood vessels, while neovascularization is the process ofde novo血管形成或由先前存在的血管形成新血管。
血管生成和新血管形成是与新血管形成有关的两个术语。血管生成是由先前存在的血管形成新血管。另一方面,新血管形成是通过诸如机制的自然形成新血管de novo血管形成或由先前存在的血管形成新血管。现有脉管系统的重塑以创建侧支动脉,也可以解释为一种新血管形成过程。
内容
1.Overview and Key Difference
2.什么是血管生成
3.What is Neovascularization
4.Similarities Between Angiogenesis and Neovascularization
5。Side by Side Comparison – Angiogenesis vs Neovascularization in Tabular Form
6。概括
什么是血管生成?
Angiogenesis is the most common type of new blood vessel formation during growth and development. Angiogenesis takes place through the formation of new vessels from pre-existing vessels. This process occurs through the sprouting of newcapillariesfrom post-capillary venules. It requires precise coordination of multiple steps. This process involves multiple cell types participating and communicating.
This complex process is initiated by the local response to tissueischemia or hypoxia. It leads to realising of angiogenic factors such as vascular endothelial growth factor (VEGF) and hypoxia-inducible factors (HIFs). The vascular endothelial growth factor is a signal protein produced by fibroblast, which stimulates the formation of new blood vessels. Hypoxia-inducible factors are transcription factors that respond to the reduction in available oxygen in the cellular environment. And, releasing these factors leads tovasodilation并增加了血管通透性。这个过程刺激发芽的血管生成或肠胃us依的血管生成。
Angiogenesis is a normal vital process in growth and development. It also helps in wound healing and in the formation of granulation tissue. However, it is also the fundamental step to the transition of benign cancer to a malignant one. Scientists use angiogenesis inhibitors in the treatment of cancer.
什么是新血管形成?
新血管形成是通过两者在体内形成新血管的自然过程de novo形成和预先存在的血管。一词血管生成是de novoformation of new blood vessels. This primarily takes place in developing embryos, but it also occurs with post-natal vascularization. Neovascularization comprises three different pathways: vasculogenesis, angiogenesis, and arteriogenesis. Angiogenesis is the most typical type of neovascularization observed in development and growth. The process of flow-related remodelling of existing vasculature to create collateral arteries is known as arteriogenesis.
The growth factors that inhibit neovascularization include those that affect the processes of endothelial cell division and differentiation. These growth factors can act as autocrine or paracrine methods. The above growth factors include fibroblast growth factor, placental growth factor, insulin-like growth factor, hepatocyte growth factor and platelet-derived endothelial growth factor.
血管生成和新血管形成之间有什么相似之处?
- They are two mechanisms of new blood vessels formation.
- 两种机制对于在整个人体中分配氧气和营养物质都非常重要。
- 生长因子这两个过程中发挥关键作用es
- Both processes may trigger cancers when they become abnormal.
What is the Difference Between Angiogenesis and Neovascularization?
Angiogenesis primarily refers to the formation of new blood vessels from pre-existing blood vessels. In contrast, neovascularization is thede novo血管形成或由先前存在的血管形成新血管。So, this is the key difference between angiogenesis and neovascularization. Furthermore, angiogenesis increases 2-3X increase in blood flow. In contrast, neovascularization increases more than a 20-30X increase in blood flow.
此外,主要涉及血管生成的生长因子是血管内皮生长因子和缺氧诱导因子,而新生血管形成的生长因子是成纤维细胞生长因子,胎盘生长因子,胰岛素样生长因子,肝细胞生长因子和血小板衍生的内皮细胞生长因子生长因子。因此,这是血管生成和新血管形成之间的另一个重要区别。
Below is a list of differences between angiogenesis and neovascularization in tabular form for side by side comparison.
摘要 - 血管生成与新血管形成
Angiogenesis refers to the formation of new blood vessels from pre-existing blood vessels, while neovascularization is the natural formation of new blood vessels through mechanisms such asde novo血管形成或由先前存在的血管形成新血管。这也是对现有脉管系统进行重塑以创建侧支动脉的一种方式。因此,这是血管生成和新血管形成之间差异的摘要。
Reference:
1. “Angiogenesis.” Wikipedia, Wikimedia Foundation, 28 Feb. 2021,Available here.
2. “Neovascularization.” Wikipedia, Wikimedia Foundation, 14 Jan. 2021,Available here.
Image Courtesy:
1. “Angiogenesis 2” By Вячеслав Евдокимов – Own work(CC BY-SA 3.0)viaCommons Wikimedia
2.通过NIH图片库(CC BY-NC 2.0)viaFlickr
发表评论