Thekey differencebetween ace inhibitors and angiotensin receptor blockersis that ace inhibitors are a class of medication that inhibit the activity of angiotensin-converting enzymes and decrease thehigh blood pressureof the human body, while angiotensin receptor blockers are a class of medication that inhibits the activity of angiotensin II receptor type 1 and decrease the high blood pressure of the human body.
Ace inhibitors and angiotensin receptor blockers are a group of pharmaceuticals used to treat high blood pressure, especially in conditions such as severe heart failures and kidney damages. Furthermore, these medications have similar mechanisms. Therefore, they either inhibit a specific receptor or an important molecule such as the enzyme in renin–angiotensin system.
内容
1.Overview and Key Difference
2.什么是ACE抑制剂
3.什么是血管紧张素受体阻滞剂
4.Similarities – Ace Inhibitors and Angiotensin Receptor Blockers
5.ACE抑制剂与血管紧张素受体阻滞剂的表格形式
6。摘要 - ACE抑制剂与血管紧张素受体阻滞剂
什么是ACE抑制剂?
Angiotensin converting enzymeinhibitorsor Ace inhibitors are a class of medication that inhibits the activity of angiotensin-converting enzymes and decrease the high blood pressure of the human body. They are primarily used for the treatment of high blood pressure and heart failure. Ace inhibitors usually cause the relaxation of blood vessels. They decrease the blood volume as well. This leads to lower blood pressure and a decrease in oxygen demand from the heart.
ACE抑制剂抑制的血管紧张素转换酶是肾素 - 血管紧张素系统的重要组成部分。该酶转化angiotensin I to angiotensin II。It also hydrolyses bradykinin. Angiotensin II is a血管收缩that increases blood pressure. Hence, ace inhibitors decrease the formation of angiotensin II. At the same time, ace inhibitors increase the level of bradykinin, which is a血管扩张器。因此,这些过程降低了人体的高血压。
Furthermore, ace inhibitors are used by doctors to decrease excessive water consumption in people with schizophrenia that have psychogenic polydipsia. Frequently prescribed ace inhibitors include benazepril, captopril, enalapril, lisinopril, perindopril, ramipril, trandolapril, and zofenopril. The common side effects of ace inhibitors are very low blood pressure, cough, dizziness, headache, fatigue, nausea, hyperkalemia, chest pain, rash, increased uric acid level, angioedema (swelling of the skin due to build-up of fluids), sun sensitivity, increased BUN & creatinine levels and kidney impairment. This drug is not recommended during pregnancy.
什么是血管紧张素受体阻滞剂?
Angiotensin receptor blockers(ARB)是一类药物,可抑制血管紧张素II受体1型(AT1)的活性,并降低人体的高血压。它也称为AT1受体拮抗剂。它们的主要用途是治疗高血压,糖尿病神经病和充血性心力衰竭。
他们选择性地阻断了血管紧张素II受体1型受体的激活,与ACE抑制剂相比,血管紧张素II的结合。血管紧张素受体阻滞剂被指示为患有高血压的患者以及左侧心力衰竭的患者中的一线降压药。血管紧张素受体阻滞剂的常见例子包括Azilsartan,Candesartan,Eprosartan,Irbesartan,Losartan,Olmesartan,Telmisartan和Valsartan。此外,使用血管紧张素受体阻滞剂时,有些人会产生常见的副作用。这些包括头晕,体重减轻,严重的腹泻,高钾血症,消化不良,上呼吸道感染,肝衰竭和肾衰竭。此外,不建议将这种药物用于孕妇,因为它会损害发育中的胎儿。
What are the Similarities Between Ace Inhibitors and Angiotensin Receptor Blockers?
- 两种药物都会影响肾素 - 血管紧张素系统。
- 这些药物降低了高血压。
- 它们用于治疗糖尿病患者的充血性心力衰竭和肾衰竭。
- They have similar mechanisms in that they inhibit specific receptors or an important molecule like an enzyme in the renin–angiotensin system.
- Both are not recommended to use during pregnancy.
ACE抑制剂和血管紧张素受体阻滞剂有什么区别?
ACE抑制剂是一类药物,可抑制血管紧张素转化酶的活性并降低人体的高血压,而血管紧张素受体阻滞剂是一种抑制血管紧张素II受体1型的活性的药物人体的血压。因此,这是ACE抑制剂和血管紧张素受体阻滞剂之间的关键区别。此外,与血管紧张素受体阻滞剂相比,ACE抑制剂会产生较少的不良反应。
以下信息图显示了ACE抑制剂和血管紧张素受体阻滞剂以表格形式的差异。
摘要 - ACE抑制剂与血管紧张素受体阻滞剂
High blood pressure is a common condition in people. Long term high blood pressure may eventually cause health problems such as congestive heart failure. Ace inhibitors and angiotensin receptor blockers are a group of pharmaceuticals that can treat high blood pressure. Ace inhibitors are a class of medication that inhibits the activity of angiotensin-converting enzymes. Angiotensin receptor blockers are a class of medication that inhibits the activity of angiotensin II receptor type 1. Thus, this is the summary of the difference between ace inhibitors and angiotensin receptor blockers.
Reference:
1.“”What Do ACE Inhibitors Do for Heart Health?”梅奥诊所,梅奥医学教育与研究基金会,2019年8月20日。
2. “What to Know about Angiotensin II Receptor Blockers。” Mayo Clinic, Mayo Foundation for Medical Education and Research, 16 Aug. 2019.
Image Courtesy:
1.“”拉米普里血压胶囊图像8“ 经过Doctor 4U(CC由2.0)通过Flickr
2. “eprosartan合成“ 经过Nuklear – Own work(CC BY-SA 4.0)通过Commons Wikimedia
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