The key difference between reversible and irreversible anticholinesterase is that reversible anticholinesterases bind to AChE non-covalently, and the enzyme can regain its function over time, while irreversible anticholinesterases bind to AChE covalently, and the enzyme is permanently inactivated leading to prolonged effects. Acetylcholinesterase (AChE) inhibitors or anticholinesterase inhibit the cholinesterase enzyme from breaking down acetylcholine […]